Sam and Dean come in contact with a rabbit's foot that gives them good luck until a thief steals it from Sam, giving him bad luck. His bad luck continues when he's kidnapped by the mentor of a hunter who believes he still has his powers.
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The seemingly harmless practices of a group of neighborhood witches goes bad when one of them kills a woman. Ruby offers her assistance... but she has a few secrets of her own.
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Dean interrogates a college student after the death of Dr. Greggs. Bobby, Sam and Dean all discover the truth behind the fatal death when they all get locked in a nightmare of their own.
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The town of Milan, Ohio, is plagued by a series of calls where the victims are contacted by dead loved ones, and urged to commit suicide. When Dean and Sam investigate, Dean gets a call of his own and the two brothers are soon at odds.
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Sam and Dean discover a doctor who, back in 1816, became obsessed with finding the secret of eternal life by taking people's vital organs. Meanwhile, Bobby finds Bela and Dean leaves Sam to confront her.
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Ghosts of children Bobby couldn't save cripple him with guilt and Sam and Dean must save him. However, they must also ignore the spirits of Meg and Agent Hendricksen, who have come back to accuse the brothers of failing them.
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