A group of angels hunts Castiel. Dean & Sam race to find their friend before the angels do. Homeless, Castiel tries to make his way through the city and comes across some unexpected surprises.
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Sam & Dean meet Dorothy from Oz and the wicked witch when they locate an ancient computer in the Men of Letters house that dislodges a hidden hex bag that unleashes a magical green-webbed wall. Dorothy became trapped in the web years ago.
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An angel war begins and a massive amount of angels are slaughtered. Sam and Dean investigate and run into Castiel who is soon captured and tortured. Dean questions Ezekiel's demands and wonders if it is time to tell Sam the truth.
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Dean hunts the angel who killed Kevin and tries to separate Sam's brain from an angels mind in order to expel Gadreel. However, the only person who knows how to do that is Crowley.
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Crowley, who wants to reclaim his place as king of hell, seeks Dean's help to find the first blade, the only blade that can kill Abbadon. Unfortunately, Cain, the first-born son, controls it.
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Sam and Dean visit Garth in the hospital and demand to know where he has been. Garth runs away and the guys investigate why he fled and are stunned by what they uncover.
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Sam and Dean work undercover at a spa to investigate murders in which the victims were hundreds of pounds lighter after their deaths. All of the victims attended the spa for weight loss; and the brothers suspect that witches are to blame.
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Sam visits a town where ordinary people are turning into violent murderers. His investigation reveals that the Men of Letters came to the town in 1958.
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