Dean and Sam investigate the death of a young college student who died in a car accident, but whose grave is now surrounded by a circle of dead plants.
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Sam and Dean meet Andy Gallagher, a slacker with psychic powers of persuasion. Once the brothers learn that Andy's family was visited by the Demon, Sam wonders if he could be one of the special children.
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Sam and Dean investigate the slayings of blonde women and find that the ghost of the first known serial killer in US history is responsible. Jo disobeys Ellen's wishes and follows them along, and is captured by the ghost.
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Dean calls a demon to make a deal to save a man named Evan Hudson, in exchange for himself. While making the deal, the demon confronts Dean's worst nightmare about their dad.
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The Winchester brothers seek the help of their family friend Bobby while investigating a series of unexplained happenings on a local college campus.
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Seven demons, based on the Seven Deadly Sins, are released into the world and the brothers must combat them with the aid of a married Hunter couple.
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Sam and Dean track down Changelings that are pursuing mothers and their children. A boy they protect bears a resemblance to Dean, which at first makes Dean uncomfortable because he once had a one-night stand with the boy's mother Lisa.
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Sam and Dean come in contact with a rabbit's foot that gives them good luck until a thief steals it from Sam, giving him bad luck. His bad luck continues when he's kidnapped by the mentor of a hunter who believes he still has his powers.
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