In the aftermath of the car crash, the surviving Winchesters go to the hospital, where one is stalked by a Reaper while another must consider sacrificing himself to save the others.
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Dean calls a demon to make a deal to save a man named Evan Hudson, in exchange for himself. While making the deal, the demon confronts Dean's worst nightmare about their dad.
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Dean is killed after looking into a case about the disappearance of a man with Sam. The next morning, Sam is shocked to find Dean alive and is hit with the realization he is reliving the day before.
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Sam and Dean are transported to an alternate universe, where they are actors on a TV show called Supernatural and are named Jared Padalecki and Jense Ackles, and they must avoid an angelic hit man who is pursuing them.
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Amara causes a small town to go mad when she places a dark fog upon it; Sam, Dean and the sheriff try to protect the town, but the old remedy fails.
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Sam, Dean and Castiel are transported into the animated world of Scooby Doo; and they join forces with the Scooby gang to solve a ghostly mystery.
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Sam and Dean look to occult lore for a solution to their latest problem, but instead of a resolution, they find much more than either of them had anticipated. This is the series 300th episode.
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About
Twenty-six years ago, Sam Winchester and Dean Winchester lost their mother to a mysterious and demonic supernatural force. Subsequently, their father John raised them to be soldiers. He taught them about the paranormal evil that lives in the dark corners and on the back roads of America... he taught them how to kill it.
