In addition to his starring role on Castle, Nathan Fillion was a recurring star on Desperate Housewives, playing Dr. Adam Mayfair, the new neighbor on Wisteria Lane and much younger husband of Katherine Mayfair (Dana Delany). On the big screen he was seen in the independent feature Trucker, starring opposite Michelle Monoghan.
Fillion's other film credits include Waitress, a romantic comedy with Keri Russell; the Universal film Slither, co-starring Elizabeth Banks; White Noise 2; Serenity, which reunited him with director Joss Whedon; Saving Private Ryan; the independent film Water's Edge; Blast from the Past; Dracula 2000 and Doubting Reilly. On television he earned an Emmy nomination for his role in the daytime drama One Life to Live. Other TV credits include the series Drive, Two Guys and a Girl, Buffy the Vampire Slayer, Pasadena and Miss Match.
A native of Edmonton, Alberta, Fillion wanted to be a high school teacher and studied at the University of Alberta. He later starred in productions at the Edmonton Fringe Festival and performed with comedy groups in town before moving on to pursue an acting career in New York and Los Angeles.