- Kelly Rowan
Natalie Vincent (Kelly Rowan) is Pierce's hallucinatory best friend and every bit his intellectual equal. According to Pierce's recollection, they met in grad school and although they dated briefly they have remained close platonic friends ever since. When Pierce meets Natalie's real-world counterpart, Dr. Caroline Newsome (also played by Rowan), the imaginary relationship he's always known becomes very real. But the line between reality and fantasy continues to blur as Pierce juggles relationships with the two identical characters.